From Illinois: Take I-57 to Exit 30 at Anna/Jonesboro, follow Highway 146 to Route 3 south, turn left on Route3/Highway 146 and turn right on Highway 146 again to take the bridge over the Mississippi River. Follow 146 to the stop light at Sprigg Street and turn right. The Show Me Center is 2 miles down on the left side of the street.
From Kentucky: Take US 60 from Paducah to Cairo. Go through Cairo and pick up Illinois Route 3. Go north on Route 3 to Highway 146 bridge route over the Mississippi River. Follow 146 to the stop light at Sprigg Street and turn right. The Show Me Center is 2 miles down on the left side of the street.
From Missouri: Take I-55 north or south bound depending on your starting point.
If coming from the North, follow I-55 South and take exit 99, turn left on Kingshighway and follow to the Broadway intersection, turn left on Broadway and continue until Sprigg Street. Turn left on Sprigg Street for approximately 1 mile and the Show Me Center will be on the left hand side of Sprigg Street.
If coming from the South, follow I-55 North to Exit 95 and turn right on Highway 74. Follow Highway 74 to the Sprigg Street intersection and turn left on Sprigg Street. Follow Sprigg street approximately 2 miles and the Show Me Center will be on your left hand side.